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Article10.1096/fasebj.27.1_supplement.1185.10

Coronary artery reactivity is increased in the aged SHR, a model of postmenopausal vascular physiology.

Joseph C. McCarthy,Rebecca Gerevics,Rolando Ramirez,Jacqueline Novak-2013-04-01-The FASEB Journal
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TL;DRAbstract

Women have a decreased risk of cardiovascular disease compared to men until after menopause when the risk is similar between men and women. The mechanism for cardioprotective effect is unclear. In order to study the physiological changes which occur in the cardiovascular system of women after menopause it is necessary to identify animal models. One model of post‐menopausal physiology is the aged spontaneously hypertensive female rats (SHR). The endocrine and blood pressure changes have been previously reported by Reckelhoff and colleagues. However, the vascular changes have not been characterized. The purpose of this study was to characterize the vascular behavior of coronary arteries in the aged female SHR. Septal coronary arteries were isolated from old and young SHR and studied in a pressure arteriograph. Active and passive diameters were measured over a range of pressures ranging from 10 to 100mmHg. Percent tone was calculated (1‐(Dactive‐Dpassive)*100%) at each pressure step. At e

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Women have a decreased risk of cardiovascular disease compared to men until after menopause when the risk is similar between men and women. The mechanism for cardioprotective effect is unclear. In order to study the physiological changes which occur in the cardiovascular system of women after menopause it is necessary to identify animal models. One model of post‐menopausal physiology is the aged spontaneously hypertensive female rats (SHR). The endocrine and blood pressure changes have been previously reported by Reckelhoff and colleagues. However, the vascular changes have not been characterized. The purpose of this study was to characterize the vascular behavior of coronary arteries in the aged female SHR. Septal coronary arteries were isolated from old and young SHR and studied in a pressure arteriograph. Active and passive diameters were measured over a range of pressures ranging from 10 to 100mmHg. Percent tone was calculated (1‐(Dactive‐Dpassive)*100%) at each pressure step. At e

Keywords

MedicineMenopauseInternal medicineBlood pressureCardiologyVascular diseaseCoronary artery diseasePostmenopausal women

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