User Settings
Article

The therapeutic potential of subpopulations of olfactory glia for neural repair

James A. St John,Jenny Ekberg-2012-01-01-Griffith Research Online (Griffith University, Queensland, Australia)
0

TL;DRAbstract

The glia of the olfactory system, olfactory ensheathing cells (OECs) are excellent candidates for neural repair. In their natural environment within the olfactory system, OECs are present within the peripheral nervous system and the central nervous system and they are considered to be crucial to the ability of olfactory neurons to regenerate throughout life. However, OECs are not a uniform population. Instead there are different subpopulations, each with a different molecular profile and proposed role in vivo. If OECs are to be used for neural repair therapies, it is therefore important to consider the different characteristics of the various subpopulations of OECs and their potential therapeutic benefit. Using in vitro assays, we have determined that OECs derived from the peripheral nervous system in the nasal cavity respond differently to OECs isolated from the olfactory bulb in the central nervous system. Peripheral OECs are a uniform population that predominantly adhere to each and

Chat with Paper

AI Agents for this Paper

The glia of the olfactory system, olfactory ensheathing cells (OECs) are excellent candidates for neural repair. In their natural environment within the olfactory system, OECs are present within the peripheral nervous system and the central nervous system and they are considered to be crucial to the ability of olfactory neurons to regenerate throughout life. However, OECs are not a uniform population. Instead there are different subpopulations, each with a different molecular profile and proposed role in vivo. If OECs are to be used for neural repair therapies, it is therefore important to consider the different characteristics of the various subpopulations of OECs and their potential therapeutic benefit. Using in vitro assays, we have determined that OECs derived from the peripheral nervous system in the nasal cavity respond differently to OECs isolated from the olfactory bulb in the central nervous system. Peripheral OECs are a uniform population that predominantly adhere to each and

Keywords

Olfactory bulbOlfactory ensheathing gliaBiologyNeuroscienceOlfactory systemCentral nervous systemPopulationNervous system

Chat

Click to start Chat