The neuroanatomy of inhibitory control in healthy aging: Evidence from event-related fMRI

TL;DRAbstract

Working memory is an important cognitive function for selecting, maintaining, and manipulating relevant information and thoughts. Inhibitory control, or the ability to suppress irrelevant or interfering stimuli, is a crucial component of working memory. Impaired inhibitory control has been proposed to account for decreased efficiency in cognitive processing for older adults, particularly in working memory tasks. Previous imaging studies with older adults, although limited in number and scope, suggest that activation in older adults is more bilateral and more diffuse compared to younger adults. Three theories have been proposed to account for activation differences between younger and older adults: Recruitment, Reorganization, and Sigmoid Function. Thus, event-related fMRI was used with a response inhibition task to test these three theories and to expand on previous findings on inhibition in aging by examining successful and unsuccessful inhibition trials. Both younger and older adults

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