Die Rolle der Beta-Sekretase bei der Myelinisierung im Zentralen Nervensystem
TL;DRAbstract
BACE1, the beta-secretase, plays a significant role in the formation of amyloid, a histopathological hallmark of Alzheimer's Disease. The physiological function of BACE1 remains unclear. Recent studies showed a role in myelination. This thesis examines the role of BACE1 in central nervous system myelination. In summary, this study shows no effect of a BACE1-inhibiton on the primary myelination in the corpus callosum, contradicting the view that BACE1-mediated processing of Neuregulin-1 is necessary for cns myelination. Whether these are local differences of different cns regions has to be examined in further studies. In addition, this study showed a small but significant influence of BACE1 on corpus callosum remyelination after cuprizone treatment.
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BACE1, the beta-secretase, plays a significant role in the formation of amyloid, a histopathological hallmark of Alzheimer's Disease. The physiological function of BACE1 remains unclear. Recent studies showed a role in myelination. This thesis examines the role of BACE1 in central nervous system myelination. In summary, this study shows no effect of a BACE1-inhibiton on the primary myelination in the corpus callosum, contradicting the view that BACE1-mediated processing of Neuregulin-1 is necessary for cns myelination. Whether these are local differences of different cns regions has to be examined in further studies. In addition, this study showed a small but significant influence of BACE1 on corpus callosum remyelination after cuprizone treatment.
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