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Open AccessBook Chapter10.1007/978-0-85729-358-9_16

Life-Threatening Autoimmune Hematological Disorders

Emmanuel Andrès,Helen Fothergill,Mustapha Mecili-2011-01-01-Autoimmune Diseases
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TL;DRAbstract

Autoimmune hematological disorders include all conditions in which blood components are attacked by the immune system. The autoimmune cytopenias are a typical example, including: autoimmune thrombocytopenic purpura, autoimmune hemolytic anemia, Evans syndrome, and autoimmune neutropenia. Other autoimmune hematological disorders include acquired thrombotic thrombocytopenic purpura which is linked to the presence of anti-ADAMTS 13 autoantibodies, and acquired hemophilia – due to the presence of anticoagulation factor antibodies. All these conditions are characterized by their acute onset and often need urgent medical attention. This chapter addresses the clinical, diagnostic, and treatment options of hematological autoimmune disorders in the emergency setting.

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Autoimmune hematological disorders include all conditions in which blood components are attacked by the immune system. The autoimmune cytopenias are a typical example, including: autoimmune thrombocytopenic purpura, autoimmune hemolytic anemia, Evans syndrome, and autoimmune neutropenia. Other autoimmune hematological disorders include acquired thrombotic thrombocytopenic purpura which is linked to the presence of anti-ADAMTS 13 autoantibodies, and acquired hemophilia – due to the presence of anticoagulation factor antibodies. All these conditions are characterized by their acute onset and often need urgent medical attention. This chapter addresses the clinical, diagnostic, and treatment options of hematological autoimmune disorders in the emergency setting.

Keywords

Autoimmune hemolytic anemiaMedicineEvans syndromeImmunologyAutoantibodyThrombocytopenic purpuraThrombotic thrombocytopenic purpuraNeutropenia

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