Alcohol and HIV Seroconversion in Men Who Have Sex with Men

TL;DRAbstract

Previous findings linking alcohol consumption and HIV seroconversion among men who have sex with men (MSM) have been inconsistent. This study argues those findings may be limited by inadequate control for confounding due to time-updated factors affected by prior alcohol consumption. We examined prospective data from 3,725 HIV-seronegative MSM enrolled in the Multicenter AIDS Cohort Study (MACS). Participants made semiannual study visits from 1984-2007, self-reported alcohol consumption, and underwent HIV testing. Potential predictors of alcohol consumption were explored. Demographic and time-updated factors including smoking, self-reported depression symptoms, illicit drug use and sexual practices were considered. Associations were modeled using logistic and lognormal multivariable regression. We next examined the joint effects of alcohol consumption and unprotected receptive anal intercourse (URAI) on HIV seroconversion. At baseline, median alcohol consumption by seronegative MACS men

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