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Association of methotrexate, rheumatoid arthritis and lymphoma: report of 2 cases and literature review.

Stephen F. Kingsmore,Ben D. Hall,Nancy B. Allen,J R Rice,David S. Caldwell-1992-09-01-PubMed
76

TL;DRAbstract

We describe 2 Caucasian men with rheumatoid arthritis (RA) who developed non-Hodgkin's lymphoma of identical histological type during treatment with low dose oral weekly methotrexate (MTX). Both patients had longstanding RA and had been treated with MTX for over 2 years at time of tumor diagnosis; neither had secondary Sjögren's syndrome. The oncogenic potential of MTX and RA arthritis is reviewed.

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We describe 2 Caucasian men with rheumatoid arthritis (RA) who developed non-Hodgkin's lymphoma of identical histological type during treatment with low dose oral weekly methotrexate (MTX). Both patients had longstanding RA and had been treated with MTX for over 2 years at time of tumor diagnosis; neither had secondary Sjögren's syndrome. The oncogenic potential of MTX and RA arthritis is reviewed.

Keywords

MedicineMethotrexateRheumatoid arthritisLymphomaAntifolateArthritisInternal medicineDermatology

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