CANCER ASSOCIATED FIBROBLAST DERIVED ANGIOGENIC FACTOR MFAP5 IN OVARIAN CANCER PROGRESSION

TL;DRAbstract

Advanced stage ovarian cancer is the most lethal gynecologic malignancy. No major improvement on patient survival has been achieved in the past decade. Therefore, identification of predictive or prognostic markers and further understanding of the molecular mechanisms in ovarian cancer progression are of paramount importance. While cancer cells have always been the targets for the identification of prognostic and predictive markers, the potential for developing new diagnosis and treatments based on the tumor supporting stromal microenvironment is relatively unexplored. Using transcriptome profiling analysis on microdissected stromal and epithelial components of normal and malignant ovarian tissues, we identified a gene signature in the fibroblastic stromal component of the tumor tissue. Among the differentially expressed genes identified in microdissected cancer associated fibroblasts, microfibrillar associated protein 5 (MFAP5), which showed 10 folds increase in expression showed signi

Chat with Paper

AI Agents for this Paper