Post-therapeutic evaluation after neoadjuvant treatment: Which of the two should be prioritized, FLT-PET or FDG-PET?

TL;DRAbstract

1524 Objectives: It has been reported that 18F-fluorothymidine (FLT) could be used for evaluating post-therapeutic status with less false positive, as compared to 18F-fluorodeoxyglucose (FDG). However, it remains unknown which is more accurate when they demonstrate discrepant results. The aim of this study was to assess the prevalence of discrepancy and which yielded more accurate diagnoses. Methods: This retrospective study enrolled 11 patients with lung cancer (n=3), esophageal cancer (n=2), pancreatic cancer (n=3), oropharyngeal cancer (n=1), hypopharyngeal cancer (n=1), or cervical cancer (n=1), who underwent both FDG-PET and FLT-PET scans within one week after they have completed scheduled neoadjuvant treatment. Findings of both studies were correlated with final diagnoses determined by histopathology and/or clinical follow-up. Results: A total of 32 lesions were analyzed, which were suspected viable by either scan or confirmed to be viable by final diagnoses. Of these 32 lesions,

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