Physiological and behavioral studies of rabbit eyeblink conditioning under temporal uncertainty: Purkinje cell response and compound conditioning

TL;DRAbstract

The present study employed electrophysiological and behavioral approaches to investigate conditioned response (CR) timing and integration when rabbits were trained with a temporal uncertainty paradigm. The temporal uncertainty paradigm involved training with a mixture of two interstimulus intervals (ISIs) of 300 and 700-ms. Previous work reported that when rabbits were trained using two CS-US, the resulting CRs showed bimodal amplitude peaks (Moore & Choi, 1997). Principle activities investigated in this study included a recordings experiment designed to investigate the expression of CR integration in cerebellar Purkinje cells and experiments designed to provide normative data on CR integration at the behavioral level. The electrophysiological recording experiment investigated the topography of conditioned eyeblink responses in rabbits trained under a mixed ISI procedure is predicted by the conditioned stimulus-triggered firing of cerebellar Purkinje cells. Recordings from Purkinje

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