Antimicrobial Susceptibility Testing Systems

TL;DRAbstract

This chapter focuses primarily on commercial susceptibility testing systems currently available in the United States. Semiautomated disk diffusion and manual and semiautomated broth microdilution systems are utilized for small volumes of susceptibility testing, while larger laboratories often choose an automated broth microdilution system. The broth microdilution antimicrobial susceptibility testing (AST) systems are manufactured by four companies: bioMerieux (Durham, NC), Siemens Healthcare Diagnostics (Deerfield, IL), Becton Dickinson Diagnostics (Sparks, MD), and Thermo Scientific (Cleveland, OH; formerly TREK Diagnostic Systems). The BIOMIC V3 system (Giles Scientific, Santa Barbara, CA) has FDA clearance to read disk diffusion zone sizes and broth microdilution panel wells. AST systems include data management software that may be interfaced with a laboratory information system and offer various levels of expert system and epidemiological analyses. Expert analysis may improve work

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