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Book Chapter10.1007/978-1-59745-176-5_12

The Chromatoid Body and microRNA Pathways in Male Germ Cells

Martti Parvinen,Noora Kotaja,Durga Prasad Mishra,Paolo Sassone‐Corsi-2007-11-08-Humana Press eBooks
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TL;DRAbstract

The chromatoid body (CB) is a finely filamentous, lobulated perinuclear granule located in the cytoplasm of male germ cells. The role of the CB in the mouse has remained elusive, although it was proposed to be involved in RNA storing and metabolism. We have found that the CB is related to the RNA processing body of somatic cells and that it seems to operate as an intracellular nerve center of the microRNA (miRNA) pathway. Our findings underscore the importance of posttranscriptional gene regulation and of the miRNA pathway in the control of postmeiotic male germ cell differentiation.

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The chromatoid body (CB) is a finely filamentous, lobulated perinuclear granule located in the cytoplasm of male germ cells. The role of the CB in the mouse has remained elusive, although it was proposed to be involved in RNA storing and metabolism. We have found that the CB is related to the RNA processing body of somatic cells and that it seems to operate as an intracellular nerve center of the microRNA (miRNA) pathway. Our findings underscore the importance of posttranscriptional gene regulation and of the miRNA pathway in the control of postmeiotic male germ cell differentiation.

Keywords

Somatic cellmicroRNACell biologyBiologyCytoplasmGerm cellGermRNA

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