WE‐EF‐BRA‐11: Precision Partial‐Tumor Irradiation of Dorsal Rodent Mammary Tumors

TL;DRAbstract

Purpose: To introduce a pre‐clinical treatment technique on a micro‐irradiator to treat specific volumes of dorsal mammary tumors in BALB/c mice while sparing lungs and spine. This technique facilitates pre‐clinical investigation of tumor response to sub‐optimal radiation treatments in which a portion of the tumor is unirradiated, known as a “marginal miss”. In‐vitro data suggests that partial tumor radiations trigger a more aggressive phenotype in non‐irradiated, regional tumor cells via bystander effects. As the lung tissue is spared, the impact of marginal miss on the development of pulmonary metastasis may be assessed. Methods: End to end test was performed on three BALB/c mice as proof of concept for larger studies. 1Gy was delivered on the micro‐irradiator employing previously unexplored lateral parallel‐opposed diamond and/or triangle‐shaped beams. The margins of the treatment beam were defined using a combination of tumor palpation, barium fiducial markers, and real‐time fluoro

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