Metabolic Control Analysis Using Transient State Data

TL;DRAbstract

It is well recognized that metabolic control is complex: it involves the regulation at the gene expression level as well as the enzyme kinetic level. Extensive investigation over the past few decades has unveiled several mechanisms for regulation at the transcriptional and translationl levels, which regulate the amount of enzymes in the cell with time scales typically longer than 10 minutes. Regulation of enzyme activity at the kinetic level can occur at time scales less than a minute by ligand-binding (competitive or non-competitive)and protein modification such as phosphorylation, adenylylation, and urydylylation. In higher animals, these mechanisms are also complicated by the involvement of hormones, membrane potential, and secondary messengers. In some cases, the metabolic pathways are fully integrated with signal transduction pathways, and with gene expression at a longer time scale. Despite encouraging progress, signal transduction and gene expression in higher organisms are stil

Chat with Paper

AI Agents for this Paper