Abstract 8493: Lack of Association between Discharge Prescription of Aldosterone Antagonists and Outcomes in Medicare Beneficiaries with Heart Failure and Preserved Ejection Fraction: A Propensity-Matched Study of the OPTIMIZE-HF

TL;DRAbstract

Background: Aldosterone antagonists reduce mortality in systolic heart failure (HF). However, their effect in HF patients with preserved ejection fraction (HF-PEF) remains unclear. Propensity-matched studies can assemble balanced cohorts while remaining blinded to outcomes, and are suitable when RCTs are difficult or unethical. We examined the association of aldosterone antagonist with outcomes in a propensity-matched cohort of older HF-PEF patients. Methods: Of the 26,376 OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure) patients linked to Medicare outcomes data (through Dec 2008), 10429 patients age ≥65 years with HF-PEF (LVEF ≥40%) were discharged alive. Of these, 866 (8.3%) received a discharge prescription for aldosterone antagonists. Propensity scores for aldosterone antagonist use, estimated for each of the 10429 patients, were used to assemble a cohort of 864 pairs of patients receiving and not receiving these drugs who

Chat with Paper

AI Agents for this Paper