Pathological Features of Maternal Death From HELLP Syndrome

TL;DRAbstract

Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is a life-threatening complication of preeclampsia during pregnancy or postpartum. Serious complications occur in 12.5-65% of cases of HELLP syndrome and are associated with a maternal mortality between 1.1 and 3.4%. Despite active research for many years, the etiology of this disorder exclusive to human pregnancy has not been sufficiently clarified. In clinical practice, disseminated intravascular coagulation (DIC) is found in 4-38% of cases with HELLP syndrome. Despite the apparent correlation between the marked degree of DIC in laboratory tests and the extent of laboratory changes in HELLP syndrome and the rate of maternal complications, the manifestation of DIC is neither an initial nor a principal symptom of HELLP syndrome but rather reflects a secondary pathophysiological process of the primary disease state that can be regarded as a result of preeclampsia that was diagnosed and/or treated too late. Hepatic ru

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