TL;DRAbstract
Der p 2 (DP2), a Dermatophagoides pteronyssinus group 2 allergen, is well-known to cause airway hypersensitivity and highly associates with induction and progression of asthma. Previous studies have shown that DP2 activates several mitogen-activated protein kinase (MAPK) pathways, which is also known to mediate muscarinic receptor-induced human lung fibroblast proliferation. Airway fibroblast proliferation and the consequent fibrosis is an important pathological characteristic of chronic inflammatory and obstructive airway diseases such as asthma, COPD and Idiopathic pulmonary fibrosis - IPF. However, whether DP2 induces proliferation of airway fibroblast and the underlying mechanisms remain sketchy. The present study demonstrated that DP2 increased expression of type I-collagen, fibronectin and alpha-SMA in both mRNA and protein level. In parallel, kinase activation assay revealed that that DP2 enhanced phosphorylation of PI3K/AKT, MAPKs including mitogen-activated protein kinase kina
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Der p 2 (DP2), a Dermatophagoides pteronyssinus group 2 allergen, is well-known to cause airway hypersensitivity and highly associates with induction and progression of asthma. Previous studies have shown that DP2 activates several mitogen-activated protein kinase (MAPK) pathways, which is also known to mediate muscarinic receptor-induced human lung fibroblast proliferation. Airway fibroblast proliferation and the consequent fibrosis is an important pathological characteristic of chronic inflammatory and obstructive airway diseases such as asthma, COPD and Idiopathic pulmonary fibrosis - IPF. However, whether DP2 induces proliferation of airway fibroblast and the underlying mechanisms remain sketchy. The present study demonstrated that DP2 increased expression of type I-collagen, fibronectin and alpha-SMA in both mRNA and protein level. In parallel, kinase activation assay revealed that that DP2 enhanced phosphorylation of PI3K/AKT, MAPKs including mitogen-activated protein kinase kina
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