Physiopathologie de l'infection par le virus de Borna

TL;DRAbstract

Borna Disease Virus (BDV) is a negative, non-segmented single stranded RNA virus that causes a persistent infection of the central nervous System (CNS) in a wide variety of mammals, leading to behavioral disorders. BDV is a well known pathogen in veterinary medicine and epidemiological evidence suggests that BDV, or a BDV-like virus, could also infect humans. During this thesis, we first aimed to study the mechanism of action and the antiviral properties of nucleoside analogs against BDV. Our results show that 1-beta-D-arabinofuranosylcytosine acts as competitive inhibitor of BDV, probably at the level of the viral polymerase. We have also identified the nucleoside analog 2’-fluoro-2'-deoxycytidine (2'-FdC), a nucleoside analog that exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV. The second goal of this thesis was to clarify the ce

Chat with Paper

AI Agents for this Paper