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BACKGROUND & AIM: To determine the influence of 4,5,7-triatomic isoflavone (genistein) on uterine endometrial cancer cells. MATERIAIS AND METHODS: Uterine endometrial cancer cells (ishikawa) were cultured in vitro with different genistein concentrations, and the influence of genistein on cell proliferation and growth inhibition was detemined by 5-bromo-2'-deoxyuridine incorporation assay (BrdU). RESULTS: The concentration of genistein at 12.5~25 μmol/L could significantly enhance cell proliferation. The concentration of genistein at 100 μmol/L significantly inhibited cell proliferation. CONCLUSION: The proliferating or inhibitiory effects of genistein on endometrial cancer cells vary with genistein concentrations.
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BACKGROUND & AIM: To determine the influence of 4,5,7-triatomic isoflavone (genistein) on uterine endometrial cancer cells. MATERIAIS AND METHODS: Uterine endometrial cancer cells (ishikawa) were cultured in vitro with different genistein concentrations, and the influence of genistein on cell proliferation and growth inhibition was detemined by 5-bromo-2'-deoxyuridine incorporation assay (BrdU). RESULTS: The concentration of genistein at 12.5~25 μmol/L could significantly enhance cell proliferation. The concentration of genistein at 100 μmol/L significantly inhibited cell proliferation. CONCLUSION: The proliferating or inhibitiory effects of genistein on endometrial cancer cells vary with genistein concentrations.
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