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Characterizing Neutrophil Behavior in Zebrafish (Danio rerio) in Response to Arsenic and Glucose

Jacob R. Longfellow-2014-01-01-DigitalCommons (California Polytechnic State University)
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TL;DRAbstract

The innate immune system recognizes self from non-self and is involved in pathogen clearance. Neutrophils are innate immune cells that quickly migrate to areas of infection or wounding. Neutrophils phagocytize pathogens and produce a respiratory burst that kills infectious agents. However, inappropriate presence and function of neutrophils contributes to many chronic inflammatory diseases. Environmental toxicants and other ingested compounds are known to impact innate immunity and neutrophil behavior. Two compounds of importance to the Maine population are arsenic and glucose, due to the presence of arsenic in Maine well water and the high rate of obesity and diabetes in Maine. Since many Mainers and people worldwide are exposed to arsenic from the environment or have elevated glucose levels, it is important to understand how these compounds impact our health. To test the effects of these compounds on neutrophil behavior, we used a transgenic zebrafish line that allows for observation

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The innate immune system recognizes self from non-self and is involved in pathogen clearance. Neutrophils are innate immune cells that quickly migrate to areas of infection or wounding. Neutrophils phagocytize pathogens and produce a respiratory burst that kills infectious agents. However, inappropriate presence and function of neutrophils contributes to many chronic inflammatory diseases. Environmental toxicants and other ingested compounds are known to impact innate immunity and neutrophil behavior. Two compounds of importance to the Maine population are arsenic and glucose, due to the presence of arsenic in Maine well water and the high rate of obesity and diabetes in Maine. Since many Mainers and people worldwide are exposed to arsenic from the environment or have elevated glucose levels, it is important to understand how these compounds impact our health. To test the effects of these compounds on neutrophil behavior, we used a transgenic zebrafish line that allows for observation

Keywords

Innate immune systemZebrafishRespiratory burstImmune systemNeutrophil extracellular trapsBiologyImmunologyPopulation

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