Blood Leak-Proof Porous Vascular Grafts

doi:https://doi.org/10.1007/978-1-59259-196-1_10

Open AccessBook Chapter10.1007/978-1-59259-196-1_10

Blood Leak-Proof Porous Vascular Grafts

Jin Ho Lee,Gilson Khang,Hai Bang Lee-2000-01-01-Humana Press eBooks

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TL;DRAbstract

The design and fabrication of synthetic vascular prostheses have been a challenging area of vascular surgical research over the past 40 yr. Large-diameter, high-flow vascular replacements for use in the thoracic and abdominal aorta were first successful whenever weaves or knits of biostable polymers, such as Dacron or Teflon were used. They could be made porous, to allow easy handling, permit luminal adherence of the fibrin coagulum, and facilitate ingrowth of tissue, which will lead to a healed pseudointima. The porosity of vascular grafts plays an important role in their long-term patency and overall biological performance (1–6). Theoretically, porosity is required for transfer of fluid and ions through the graft matrix, and provides a scaffold for ingrowth of perivascular tissues.

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The design and fabrication of synthetic vascular prostheses have been a challenging area of vascular surgical research over the past 40 yr. Large-diameter, high-flow vascular replacements for use in the thoracic and abdominal aorta were first successful whenever weaves or knits of biostable polymers, such as Dacron or Teflon were used. They could be made porous, to allow easy handling, permit luminal adherence of the fibrin coagulum, and facilitate ingrowth of tissue, which will lead to a healed pseudointima. The porosity of vascular grafts plays an important role in their long-term patency and overall biological performance (1–6). Theoretically, porosity is required for transfer of fluid and ions through the graft matrix, and provides a scaffold for ingrowth of perivascular tissues.

Keywords

Vascular graftPorosityAbdominal aortaBiomedical engineeringScaffoldMedicineFibrinAorta

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