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Open AccessDissertation10.25959/23245376

Proteomic analysis of breast cancer

Kylie Roberts-2009-01-01-UTAS Research Repository
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TL;DRAbstract

Introduction: Breast cancer is a disease that will affect every woman in her life. Whether that affect will be direct or indirect is, at this stage almost impossible to determine. There have been several key findings in recent years with genes being found that are linked directly to breast cancer. With these being attributed to less than 10% of breast cancers diagnosed, the need for new biomarkers of breast cancer exists. This study aims to find new biomarkers though differential analysis of breast cancer tissue. Several different analysis have been conducted to provide insight in to potential new markers for diagnosing early onset breast cancers, looking for signs in otherwise healthy tissue and ascertaining differences between cancer and healthy tissue as a whole. This study also looks in to the functional areas of proteomic research, determining a need for further investigation in to IGF-1 and ~-casein, which have been inconclusively linked to breast cancer in the past. Methods: By

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Introduction: Breast cancer is a disease that will affect every woman in her life. Whether that affect will be direct or indirect is, at this stage almost impossible to determine. There have been several key findings in recent years with genes being found that are linked directly to breast cancer. With these being attributed to less than 10% of breast cancers diagnosed, the need for new biomarkers of breast cancer exists. This study aims to find new biomarkers though differential analysis of breast cancer tissue. Several different analysis have been conducted to provide insight in to potential new markers for diagnosing early onset breast cancers, looking for signs in otherwise healthy tissue and ascertaining differences between cancer and healthy tissue as a whole. This study also looks in to the functional areas of proteomic research, determining a need for further investigation in to IGF-1 and ~-casein, which have been inconclusively linked to breast cancer in the past. Methods: By

Keywords

Breast cancerCancerProteomicsProteomeDiseaseBiologyBioinformaticsMedicine

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