Regulation of human B lymphocytes differentiation: Characterization of B cell stimulatory factors

TL;DRAbstract

B lymphocytes originate from pluripotent hematopoietic stem cells and differentiate into antibody producing cells through several distinct differentiation stages. Commitment of the antigen specificity in each B cell clone occurs at the stage of pre B cells by two step DNA rearrangements including V, D and J segments, i.e. from DJ joining to the functional VDJ formation (1). Following the rearrangement of heavy chain genes, light chain gene rearrangements occur (2) and 7S IgM molecules are expressed as antigen receptors on the surface of mature B cells. A given antigen selects a B cell clone with a matched receptor and activates this clone into antibody producing cells under the influence of helper T cells.

Chat with Paper

AI Agents for this Paper