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Group I metabotropic glutamate receptors and sensory transmission through the thalamus: An overview

Salt, TE,J. J. Turner-2001-01-01-UCL Discovery (University College London)
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TL;DRAbstract

Metabotropic glutamate receptors (mGluRs) are found in the thalamus, and previous data has shown that these are involved in the physiological nociceptive responses of thalamic neurones. In order to characterise the receptor(s) mediating this response more fully, we have carried out experiments with the novel antagonist LY367385 (S-2-methyl-4-carboxy-phenylglycine) and the agonist R,S-2-chloro-5-hydroxyphenylglycine. Our results show that there appear to be both functional mGluR1 and mGluR5 receptors in the ventrobasal thalamus, with the former possibly predominating, Activation of these receptors gives rise to an excitatory response in vivo, and in vitro recordings show a depolarising effect associated with an increase in membrane resistance. Such response characteristics would be well suited to exert a slow synaptic response or modulatory influence. Nociceptive responses of thalamic neurones in vivo are reduced by the mGluR1-selective LY367385, indicating that they are partially depen

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Metabotropic glutamate receptors (mGluRs) are found in the thalamus, and previous data has shown that these are involved in the physiological nociceptive responses of thalamic neurones. In order to characterise the receptor(s) mediating this response more fully, we have carried out experiments with the novel antagonist LY367385 (S-2-methyl-4-carboxy-phenylglycine) and the agonist R,S-2-chloro-5-hydroxyphenylglycine. Our results show that there appear to be both functional mGluR1 and mGluR5 receptors in the ventrobasal thalamus, with the former possibly predominating, Activation of these receptors gives rise to an excitatory response in vivo, and in vitro recordings show a depolarising effect associated with an increase in membrane resistance. Such response characteristics would be well suited to exert a slow synaptic response or modulatory influence. Nociceptive responses of thalamic neurones in vivo are reduced by the mGluR1-selective LY367385, indicating that they are partially depen

Keywords

Metabotropic glutamate receptorNeuroscienceMetabotropic glutamate receptor 1Metabotropic glutamate receptor 5ThalamusMetabotropic receptorGlutamate receptorExcitatory postsynaptic potential

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