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纤维素-三(3,5-二甲基苯基氨基甲酸酯)手性柱的制备及应用

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TL;DRAbstract

Cellulose tris (3, 5-dimethyiphenylcarbamate) (CDMPC) were synthesized by the reaction of micrystalline cellulose with 3, 5-dimethyiphenylisocyanate in dry pyridine at 110℃. Elemental analysis and IR spectra indicated that most of the hydroxy groups of the microcrystalline cellulose had been converted into ester groups. The chiral stationary phases(CSP) were prepared by mating cellulose tris (3, 5-dimethylphenylcarbamate) on the aminopyopyl silica. The evaluation of column was achieved hexane/2-propanol (90: 10 volume ratio) as mobile phase at a flow rate of 1mL•min 1(at 25℃). And the results of the separation of chiral compound showed that the chiral stationary has good steroelectivity.

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Cellulose tris (3, 5-dimethyiphenylcarbamate) (CDMPC) were synthesized by the reaction of micrystalline cellulose with 3, 5-dimethyiphenylisocyanate in dry pyridine at 110℃. Elemental analysis and IR spectra indicated that most of the hydroxy groups of the microcrystalline cellulose had been converted into ester groups. The chiral stationary phases(CSP) were prepared by mating cellulose tris (3, 5-dimethylphenylcarbamate) on the aminopyopyl silica. The evaluation of column was achieved hexane/2-propanol (90: 10 volume ratio) as mobile phase at a flow rate of 1mL•min 1(at 25℃). And the results of the separation of chiral compound showed that the chiral stationary has good steroelectivity.

Keywords

Microcrystalline celluloseCelluloseTrisChemistryElemental analysisPyridineNuclear chemistryOrganic chemistry

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