Self-assembling hydrogels for cartilage engineering purposes

TL;DRAbstract

Completely recovering therapies for patients with articular cartilage defects, due to for example sport- or car incidents, are still not there. Therefore, current medical studies focuses on the development of new articular cartilage repairing strategies. There is increasing interest in the field of tissue engineering to develop such therapy. Biomaterials play an essential role in the development of proper functional engineered tissue. Articular cartilages' intrinsic function is to provide a smooth joint surface which can withstand big mechanical loadings. As a consequence, the biomaterials which will be developed for articular cartilage studies should meet to this biomechanics, and should enable the incorporation of chondrogenic cells and (growth) factors. Self-assembling biomaterials are a relatively new material, which are molecules that form a network via a non-covalent bound, which is a highly dynamically and spontaneous process. This facilitates several beneficial aspects. These a

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