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Open AccessParatext10.1371/journal.pone.0109782.g006

A consolidated model for the role of the miR-545/374a cluster in human HBV related hepatocellular carcinoma.

Qi Zhao,Tao Li,Jianni Qi,Juan Liu,Chengyong Qin-2015-12-02-Figshare
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TL;DRAbstract

<p>Ftx gene encodes a lncRNA which harbors 2 cluster of microRNAs in its introns, the miR-374a/545 cluster and the miR-374b/421 cluster. In clinical specimens, the miR-545/374a cluster is upregulated in HCC tissue and is significantly correlated with prognosis-related clinical features. Serum miR-545/374a are tumor-derived, and their expression are significantly decreased after surgical excision of tumor tissue. MicroRNA 545 and miR-374a are both higher in male HCC patients compared to female HCC patients, and ESRRG may be a target gene of miR-545. In vitro studies, the miR-545/374a cluster promotes HCC cell proliferation, cell migration and invasion. Expression of miR-545/374a is positively regulated by HBV infection and may be induced by HBx expression.</p>

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<p>Ftx gene encodes a lncRNA which harbors 2 cluster of microRNAs in its introns, the miR-374a/545 cluster and the miR-374b/421 cluster. In clinical specimens, the miR-545/374a cluster is upregulated in HCC tissue and is significantly correlated with prognosis-related clinical features. Serum miR-545/374a are tumor-derived, and their expression are significantly decreased after surgical excision of tumor tissue. MicroRNA 545 and miR-374a are both higher in male HCC patients compared to female HCC patients, and ESRRG may be a target gene of miR-545. In vitro studies, the miR-545/374a cluster promotes HCC cell proliferation, cell migration and invasion. Expression of miR-545/374a is positively regulated by HBV infection and may be induced by HBx expression.</p>

Keywords

Hepatocellular carcinomaCluster (spacecraft)Hepatitis B virusBiologyComputational biologyVirologyCancer researchComputer science

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