Population-based analysis of the HLA associated risk for IDDM

TL;DRAbstract

<p>Insulin dependent diabetes (IDDM) is one of the most common chronic illnesses among children and young adults in Sweden. The disease has a complex pattern of inheritance and environmental factors are important. The strongest linkage to IDDM is found on chromosome 6p21 in the Major Histocompatibility Complex (MHC) region. A strong linkage disequilibrium in the MHC have made identification of the alleles responsible for the primary association difficult. The aim of this project was to Identify the primary association of Human leukocyte antigens (HLA) to IDDM in Swedish population-based case-control studies and to analyse the interaction of these factors age, gender and islet cell autoantibody levels. In addition the transmission of IDDM associated HLA haplotypes were investigated in patient and control families.</p><p>Patients and controls from three population-based case-control studies were HLA typed for DQA1, DQB1 and DRB. A comparison of allele frequencies betwee

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