Toxic Hazards Research Unit 1989

TL;DRAbstract

This report has been prepared as a review of the October 1988 through September 1989 activities of the Toxic Hazards Research Unit. Research activities largely focused on the toxicity of chlorotrifluoroethylene oligomers and the acid metabolic products of this material. Initial acute studies also were conducted on a silahydrocarbon hydraulic fluid. Physiologically based pharmacokinetic models were developed, refined or more substantially validated for several chemicals of Air Force and Navy interest. These included hydraulic fluids, organophosphates, and combustion products. Both in vivo and in vitro studies on chloropentafluorobenzene, a chemical defense training material, were conducted or subcontracted, and efforts were begun to develop the equipment needed for additional studies using primates. Neurotoxicity assessments were conducted for jet engine oils and a model was developed to assess the dermal penetration of a neurotoxic compound found in the combustion products of another l

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