CRY associated proteins modulate circadian transcription by regulating CRY stability

TL;DRAbstract

Circadian clocks have evolved in all light sensitive organisms from cyanobacteria to mammals. These timing systems allow the organism to adjust their physiology and behavior to the geo-physical time. In mammals the circadian clocks exist in virtually all body cells, but the system function in a hierarchical manner in which the master pacemaker in the suprachiasmatic nucleus (SCN) sets the pace of the subsidiary peripheral oscillators. SCN is a small, approximately 10 000-20 000 cells, neuroendocrine gland in the hypothalamus. The SCN receives a direct photic input from the retina through the retino-hypothalamic tract and transmits this information to the oscillators in the periphery using neuronal and humoral signals. The molecular clock both in the SCN and in the peripheral oscillators is thought to consist of negative transcriptional and translational feedback loops. The PAS domain basic helix-loop-helix transcription factors BMAL1 and CLOCK bind to the promoters and transactivate tw

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