Desarrollo de un método de cromatografía capilar electrocinética micelar para la determinación de 5-nitroimidazoles en aguas de río

TL;DRAbstract

5-nitroimidazoles (5-NDZs) represent a group of antibiotics with antiprotozoal and antibacterial properties. Some of them, as metronidazole, tinidazole and ornidazole, are used in human medicine, although they have had veterinary applications too. Since 90’s, the use of 5-NDZs in food-producing animals is forbidden by the European Union because these compounds and their metabolites possess genotoxic, carcinogenic and mutagenic properties. In this sense, Commission Regulation N. 37/2010 establishes that no residue of any 5-NDZs can be found in animals products intended for human consumption. However, they are still used as veterinary antibiotics according to the food alerts published in the Rapid Alert System for Food and Feed (RASFF) portal. Besides, 5-NDZs and their metabolites are very soluble in water and their biodegradability is low, so their presence in fish-farm water and meat industry effluents can produce their bioaccumulation. Considering that the capacity of current water tr

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