Programowana śmierć komórki a białka z rodziny inhibitorów apoptozy (iap) i ich rola w nowotworzeniu

TL;DRAbstract

Apoptosis is a natural physiological process, intended to eliminate some cells. Incorrect, damaged or redundant cells, undergo programmed cell death. Initiation of the apoptosis proceeds under the influence of extracellular factors and activation of membrane receptors or involves mitochondrion activity and a disruption of intracellular homeostasis. A crucial role in regulation of the apoptosis is played by the Bcl-2 family proteins, which include pro- and anti-apoptotic proteins. The relation between these proteins determines which pathway leading to the cell death will be entered. Apoptosis may be inhibited in several ways, for example by heat shock proteins (HSP) or by inhibitors of apoptosis (IAP). IAP inhibit initiation of the process by binding to effector proteins of the execution phase of apoptosis or by leading them to the proteasomal degradation. Genes of IAP were identified for the first time in baculoviruses. In a human, eight IAP proteins, grouped into three classes, were i

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