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AIM: To investigate the expression of E-cadherin, β-catenin and Cyclin D1 and their relationships and clinical pathological features in gastric adenocarcinoma. METHODS: Immunohistochemical SP method was used to determine the expression of E-cadherin, β-catenin and Cyclin D1 protein in 73 cases of gastric adenocarcinoma tissues and 18 cases of normal gastric mucosal tissues. RESULTS: Positive staining for E-cadherin and β-catenin was observed on the cellular membrane of epithelial cells in normal gastric mucosal tissues. The aberrant expression of E-cadherin and β-catenin were observed in the cytoplasm and/or cellular nucleus of gastric cancer cells. The aberrant expression rates of E-cadherin and β-catenin were 63.01%(46/73) and 56.16%(41/73) in gastric adenocarcinoma, respectively, which were associated with the differentiation degree, TNM stages, depth of infiltration and lymph node metastasis, but not with the gender, age and tumor size. There was a significant correlation between E
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AIM: To investigate the expression of E-cadherin, β-catenin and Cyclin D1 and their relationships and clinical pathological features in gastric adenocarcinoma. METHODS: Immunohistochemical SP method was used to determine the expression of E-cadherin, β-catenin and Cyclin D1 protein in 73 cases of gastric adenocarcinoma tissues and 18 cases of normal gastric mucosal tissues. RESULTS: Positive staining for E-cadherin and β-catenin was observed on the cellular membrane of epithelial cells in normal gastric mucosal tissues. The aberrant expression of E-cadherin and β-catenin were observed in the cytoplasm and/or cellular nucleus of gastric cancer cells. The aberrant expression rates of E-cadherin and β-catenin were 63.01%(46/73) and 56.16%(41/73) in gastric adenocarcinoma, respectively, which were associated with the differentiation degree, TNM stages, depth of infiltration and lymph node metastasis, but not with the gender, age and tumor size. There was a significant correlation between E
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