Neuroinflammatory Regulation of Stress Behavior and Physiology

TL;DRAbstract

Neuropsychiatric diseases represent a major public health burden worldwide; due to gaps in our understanding of the pathogenic mechanisms of disease, approximately 30% of patients are refractory to treatment. Activation of neuroinflammatory signaling cascades has shown promise as a contributing factor for disease development. This hypothesis is driven in part by an intriguing overlap of symptoms in patients with neuropsychiatric and immunological disorders. Patients with depression, bipolar disorder, schizophrenia, and autism commonly present with immune dysfunction, while patients with multiple sclerosis, lupus, and rheumatoid arthritis often experience severe mood disturbances. Diversity in presentation of symptoms, however, has posed a research challenge to our mechanistic understanding of this link. In contrast to the complexity of modeling specific diseases, altered sensitivity to stress is a well-documented vulnerability marker across neuropsychiatric disorders. Of relevance to c

Chat with Paper

AI Agents for this Paper