Survival and progression of HIV disease in women attending GUM/HIV clinics in Britain and Ireland

TL;DRAbstract

Objectives: To describe the pattern of clinical disease in women with HIV infection and to examine the effect of potential cofactors, including oral contraceptive use, alcohol and smelting, ethnic group, and route of HIV transmission, on progression to AIDS and death.Design: Prospective observational cohort study.Setting: 15 HIV and genitourinary medicine (GUM) clinics in Britain and Ireland.Participants: 505 women aged over 18 years with a positive HIV antibody test entered the study between June 1992 and August 1995, with outcome data available for 503 women, and 1208 woman years of follow up to April 1996.Main outcome measures: AIDS defining conditions, incidence of AIDS, and death.Results: 120 women (24%) had AIDS at entry to the study. There were 99 incident AIDS cases and 132 deaths during 1208 woman years of follow up. Pneumocystis carinii pneumonia (PCP) was the commonest first AIDS defining condition in white women (31% of AIDS cases), followed by oesophageal candidiasis (19%)

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