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Book Chapter10.1007/978-1-59745-292-2_18

Cooperation Between TGF-β and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function

Irwin M. Liu,Stephen H. Schilling,Xiao‐Fan Wang-2008-01-01-Humana Press eBooks
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TL;DRAbstract

Stem cells have become a subject of intensive research based on their potential for varied clinical applications. One such stem cell, the mesenchymal stem cell, has attracted attention owing to its ability to differentiate into several mesenchymal lineages such as bone, cartilage, and fat. The molecular pathways which regulate the functions of mesenchymal stem cells are not well-characterized, but the TGF-β and Wnt signaling pathways are thought to play critical roles. Here, we describe the importance of TGF-β and Wnt signaling pathway crosstalk in governing mesenchymal stem cell function.

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Stem cells have become a subject of intensive research based on their potential for varied clinical applications. One such stem cell, the mesenchymal stem cell, has attracted attention owing to its ability to differentiate into several mesenchymal lineages such as bone, cartilage, and fat. The molecular pathways which regulate the functions of mesenchymal stem cells are not well-characterized, but the TGF-β and Wnt signaling pathways are thought to play critical roles. Here, we describe the importance of TGF-β and Wnt signaling pathway crosstalk in governing mesenchymal stem cell function.

Keywords

Mesenchymal stem cellWnt signaling pathwayCell biologyCrosstalkStem cellBiologySignal transduction

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