User Settings
Open AccessBook Chapter10.1007/978-1-4612-5250-4_18

Enveloped Virus Maturation at Restricted Membrane Domains

Richard W. Compans-1984-01-01
6PDF

TL;DRAbstract

Synthesis and assembly of the envelope proteins of lipid-containing viruses require the biosynthetic and transport processes involved in cellular membrane biogenesis, and such viruses have therefore been used extensively for investigation of these processes. With the exception of poxviruses, which assemble their membranes de novo in the cytoplasm, the assembly of enveloped viruses takes place on preformed cellular membranes. The precise location at which assembly occurs is a distinctive characteristic that is highly conserved among structurally similar viruses. Herpesvirus maturation occurs by budding at the inner nuclear membrane. Coronaviruses are assembled at the rough endoplasmic reticulum, and bunyaviruses bud at membranes of the Golgi complex. Virus particles of several other families are formed by budding at the plasma membrane. Polarized epithelial cells exhibit distinct apical and basolateral surface domains separated by tight junctions, and it has been observed that assembly

Chat with Paper

AI Agents for this Paper

Synthesis and assembly of the envelope proteins of lipid-containing viruses require the biosynthetic and transport processes involved in cellular membrane biogenesis, and such viruses have therefore been used extensively for investigation of these processes. With the exception of poxviruses, which assemble their membranes de novo in the cytoplasm, the assembly of enveloped viruses takes place on preformed cellular membranes. The precise location at which assembly occurs is a distinctive characteristic that is highly conserved among structurally similar viruses. Herpesvirus maturation occurs by budding at the inner nuclear membrane. Coronaviruses are assembled at the rough endoplasmic reticulum, and bunyaviruses bud at membranes of the Golgi complex. Virus particles of several other families are formed by budding at the plasma membrane. Polarized epithelial cells exhibit distinct apical and basolateral surface domains separated by tight junctions, and it has been observed that assembly

Keywords

BuddingEndoplasmic reticulumCell biologyViral envelopeCytoplasmMembraneGolgi apparatusBiology

Chat

Click to start Chat