THE ACTION OF HYDROXYLATED PHENYLALANINES ON THE GROWTH OF BACTERIA

TL;DRAbstract

In recent years it has been found that for various microorganisms a number of substitution products of phenylalanine are competitively antagonistic to this amino acid.Compounds in which the phenyl group of phenylalanine was replaced by heterocyclic nuclei included p-2-thienylalanine (l-4), /3-3-thienylalanine ( 5)) p-2-furylalanine ( 6)) and fl-2-pyrrolealanine (7).A phenylalanine analogue substituted in the P-carbon position, p-hydroxyphenylalanine, was studied by Beerstecher and Shive (3), and ring halogenated phenylalanines and tyrosine were prepared by Mitchell and Niemann (8).These investigations have lately been reviewed by Winzler ( 9) and by Dittmer ( 10).The present study deals with two hydroxy-substituted phenylalanines;viz., DL-o-hydroxyphenylalanine and DL-2 ,5-dihydroxyphenylalanine. Their effects on bacteria able to synthesize phenylalanine or tyrosine and on those requiring an extraneous supply of these amino acids are reported. Methods and MaterialsCultures and Media-Le

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