Biomarker für Oxidativen Stress bei Entzündungsreaktionen: Bedeutung von Genpolymorphismen und Genexpression der NADPH-Oxidase unter pro- und anti-inflammatorischen Bedingungen

TL;DRAbstract

Background NADPH oxidases (NOX) comprise a multimeric enzyme system expressed in various types of cells and tissues. The most popular isoform is that in leucocytes termed NOX2 according to the big catalytic subunit and is activatable by assembling of the cytosolic to the membrane-asscociated subunits. By transferring electrons from NADPH to oxygen NOX generates superoxid radicals, which are further metabolized to other reactive oxygen spezies (ROS). First attributed to anti-pathogen activity it was later observed that ROS are implicated in a variety of cellular processes as inflammation, proliferation, differentiation, and apoptosis. Consequently, ROS are regarded to be involved in a plethora of pathological conditions. In the recent years, the potential impact of genetic polymorphisms on the modulation of ROS formation gained increased interest. The aim of this study was to identify biomarkers for NOX2 activity as a surrogate for oxidative stress. Methods As functional trait, the NOX2

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