Pediatric Hodgkin Lymphoma-Treatment Outcome with COPDac/ABVD Combination Chemotherapy – Single Institution Experience

TL;DRAbstract

Abstract Background: We describe single center experience of using ABVD/COPDac . This regimen was adapted due to perceived excessive toxicity with OEPA/COPDac by treating physicians. Hodgkin lymphoma is being treated with multiple treatment regimens single agent or in combination. MOPP (mechlorethamine, vincristine, procarbazine and prednisolone) has been standard treatment for almost two decads. But it had significant toxic effects including infertility in both genders, myelosuppression and second malignancies . ChlvPP( chlorambucil, vincristine, procarbazine and prednisolone ) has comparable efficacy and toxicities to MOPP . ABVD( Adriamycin, bleomycin, vincristine and doxorubicin ) was mostly used as second line with high activity without permanent male sterility, myelodysplasia or risk of leukemia. Objective : We describe single center experience of using ABVD/COPDac . This regimen was adapted due to perceived excessive toxicity with OEPA/COPDac by treating physicians. Results 62 p

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