Multimodality Imaging of Reporter Genes

TL;DRAbstract

Reporter genes (RGs), an integral part of molecular imaging, have become essential tools for studying biology in living subjects noninvasively. Currently, molecular imaging techniques can be broadly classified into five categories based on the spectrum and source of energy used for detection. These are optical imaging (fluorescence and bioluminescence imaging), radionuclide imaging (positron emission tomography (PET) and single photon emission computed tomography (SPECT), X-ray computed tomography imaging (CT), magnetic resonance imaging (MRI), and ultrasound (US) imaging. Excluding CT and US, a variety of reporter genes have been developed for the remaining three categories, which can be used to study specific biological processes (such as promoter activation, transcription, translation, protein–protein interaction) and monitor disease progression and therapy (Figure 5.1). Reporter genes therefore are also categorized into different groups based on their usage for different imaging te

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