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Objective To investigate podocyte number, the expression of nephrin and transforming growth factor-β1 (TGF-β1) in adriamycin-induced-nephropathy rat model and its significance. Methods The rat adriamycin nephrosis model vas constructed to detect blood and urine biochemical indicators and observe the pathological changes of renal tissues by light microscope and electron microscope The expression levels of nephrin and TGF-β1 as well as the podocyte number were examined at different time points by immunohistochemistry. Results She pathological changes of the renal tissues were obvious Nephrin presented a weak signal at the end of the first week (P＜0.05). TGF-β1 started to increase (P＜0.05) while the podocyte number started to decrease at the end of the eighth week (P＜0.05). Expression of nephrin was negatively correlated with the 24 h urinary protein (r=-0.83, P＜0.01), blood urea nitrogen (r=-0.68, P＜0.05) and serum creatinine (r=-0.71, P＜0.05). Expression of LGF-β1 was positively correla
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Objective To investigate podocyte number, the expression of nephrin and transforming growth factor-β1 (TGF-β1) in adriamycin-induced-nephropathy rat model and its significance. Methods The rat adriamycin nephrosis model vas constructed to detect blood and urine biochemical indicators and observe the pathological changes of renal tissues by light microscope and electron microscope The expression levels of nephrin and TGF-β1 as well as the podocyte number were examined at different time points by immunohistochemistry. Results She pathological changes of the renal tissues were obvious Nephrin presented a weak signal at the end of the first week (P＜0.05). TGF-β1 started to increase (P＜0.05) while the podocyte number started to decrease at the end of the eighth week (P＜0.05). Expression of nephrin was negatively correlated with the 24 h urinary protein (r=-0.83, P＜0.01), blood urea nitrogen (r=-0.68, P＜0.05) and serum creatinine (r=-0.71, P＜0.05). Expression of LGF-β1 was positively correla
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