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[Effect of neoadjuvant chemotherapy on histologic grade and expression of biological markers in breast cancer].

Hongfang Yin,Yunhong Wang,Xiaoqi Qin,Hong Zhang,Ting Li,Jingming Ye+1 more-2009-11-01-PubMed
9

TL;DRAbstract

PR expression in breast cancer decreases after neoadjuvant chemotherapy, while ER and Her-2 expressions remain stable. After neoadjuvant chemotherapy, the histological grade and proliferation index are decreased and correlated with the response to chemotherapy. Therefore, histological grade and proliferation index may be effective complementary factors in assessment of the effectiveness of neoadjuvant chemotherapy.

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PR expression in breast cancer decreases after neoadjuvant chemotherapy, while ER and Her-2 expressions remain stable. After neoadjuvant chemotherapy, the histological grade and proliferation index are decreased and correlated with the response to chemotherapy. Therefore, histological grade and proliferation index may be effective complementary factors in assessment of the effectiveness of neoadjuvant chemotherapy.

Keywords

MedicineBreast cancerChemotherapyEstrogen receptorImmunohistochemistryOncologyInternal medicineNeoadjuvant therapy

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