Brain GABA-receptor systems in functional thyroid disorders

doi:https://doi.org/10.14341/probl200955528-30

Open AccessArticle10.14341/probl200955528-30

Brain GABA-receptor systems in functional thyroid disorders

Flora Inoyatova,A K Tonkikh,G T Yakubova-2009-10-15-Problems of Endocrinology

TL;DRAbstract

This experimental study was designed to evaluate effects of hypo- and hyperthyroidism on the density of 3H-muscimol and 3H-diazepam-binding sites in synaptic membranes of the rat brain. It was shown that density of both 3H-muscimol and 3H-diazepam-binding sites increases in animals with hypothyroidism and decreases in hyperthyroidism. This difference may account for the predominance of general inhibitory reaction in animals with hypothyroidism and general excitation in hyperthyroid rats.

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This experimental study was designed to evaluate effects of hypo- and hyperthyroidism on the density of 3H-muscimol and 3H-diazepam-binding sites in synaptic membranes of the rat brain. It was shown that density of both 3H-muscimol and 3H-diazepam-binding sites increases in animals with hypothyroidism and decreases in hyperthyroidism. This difference may account for the predominance of general inhibitory reaction in animals with hypothyroidism and general excitation in hyperthyroid rats.

Keywords

NeuroscienceThyroidReceptorMedicineBiologyEndocrinologyInternal medicine

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