Evaluating and Optimizing a Protocol for Mesodermal Differentiation of Pluripotent Stem Cells towards Cardiomyocytes and Adipocytes

TL;DRAbstract

The fat epidemic is an increasing issue in today’s society, and with it follows obesity-related diseases, such as type 2 diabetes and coronary heart disease. Many of today’s drug candidates are withdrawn from the market due to negative cardiac effect, which result in huge setbacks for drug companies if detected at late stage trials Therefore, there is a necessity of appropriate in vitro models, which can detect these toxic effects at early stages in drug development. Consequently, there is an increasing demand in providing cells with high biological relevance. A large portion of the study models used today are performed with in vitro cells lines of cancerous origin, and often from species other than human. In addition, usage of different in vivo models also add to the complexity with the matter of accurate translability. This issue can be addressed by using primary cells. However, this raises the problem of accessibility, which can almost be impracticable when it comes to accessing and

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