BEHAVIOR OF SUDAN III IN THE ANIMAL ORGANISM

TL;DRAbstract

The fat-soluble dye Sudan III, since its first preparation by Nieteki' in 1880, has been used extensively in the study of problems directly and indirectly associated with vital staining and the metabolism of fat.The work of Daddi, Gage, Riddle, Mendel, Whitehead, and many others, including that recently published by Hatai,2 has shown how fat can be traced in the body by means of oil-soluble dyes.In their paper on the behavior of fat-soluble dyes in the animal organism, Mendel and Daniels3 discussed the toxicity, absorption, transport, and excretion of this dye.They stated that it is apparently non-toxic, inasmuch as animals fed over long periods of time showed no deleterious results.When fed in solution in fat it may enter the organism from the alimentary tract through the lymphatics or by the portal circulation dissolved in reabsorbed bile, a cycle becoming established between the intestine, bile, and blood.The dye is eliminated in the feces alone, except when an alimentary lipuria ar

Chat with Paper

AI Agents for this Paper