Study of the mechanism of action of snake myotoxins

TL;DRAbstract

Envenoming due to snake bite is a neglected disease that is a very important public health problem in rural regions of Africa, Latin America and Asia. Snakes from the genus Bothrops cause most of the snake bites in Latin America. Phospholipases A2 (PLA2s) are major components of the venoms from this genus, exerting myotoxicity as one of their most relevant toxic actions. Many parts of the mechanism of action by which these proteins damage muscle cells are not known. Therefore, it is crucial to further study these toxins.
\nIn the first part of this work, the measurement of the hydrolysis of phospholipids caused by the addition of myotoxin I (Mt-I) and myotoxin II (Mt-II) from the venom of Bothrops asper to C2C12 myotubes, and the ex vivo injection of the venom of B. asper, Mt-I, and Mt-II in tibialis anterior muscles of CD-1 mice was performed. Results show that Mt-I and B. asper venom caused an increase in lysophosphatidilcholine (lysoPC) and lysophosphatidilethanolamine (lysoPE)

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