Studies of the metabolism <i>in vivo</i> of cortisol by the rat liver

TL;DRAbstract

has been studied in the rat liver with the isolated perfused organ. In these experiments the hormones were dissolved in either homologous or heterologous blood, which was then perfused through the liver and the effluent extracted for the steroid meta- bolites. Since it is possible that the results obtained by this technique might be different from those in which cortisol metabolites are isolated from liver in situ, the metabolism of cortisol by the liver was studied after its parenteral administration in the rat. EXPERIMENTAL Nomenclature Cortisol, cortisone, corticosterone, P-cortol, P-cortolone,

Chat with Paper

AI Agents for this Paper