Adolescent Loneliness and the Interaction between the Serotonin Transporter Gene (5-HTTLPR) and Parental Support: A Replication Study

doi:https://doi.org/10.1371/journal.pone.0133430

Open AccessArticle10.1371/journal.pone.0133430

Adolescent Loneliness and the Interaction between the Serotonin Transporter Gene (5-HTTLPR) and Parental Support: A Replication Study

Annette Spithoven,Patricia Bijttebier,Wim Van Den Noortgate,Hilde Colpin,Karine Verschueren,Karla Van Leeuwen+2 more-2015-07-17-PLoS ONE

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TL;DRAbstract

Gene-by-environment interaction (GxEs) studies have gained popularity over the last decade, but the robustness of such observed interactions has been questioned. The current study contributes to this debate by replicating the only study on the interaction between the serotonin transporter gene (5-HTTLPR) and perceived parental support on adolescents' peer-related loneliness. A total of 1,111 adolescents (51% boys) with an average age of 13.70 years (SD = 0.93) participated and three annual waves of data were collected. At baseline, adolescent-reported parental support and peer-related loneliness were assessed and genetic information was collected. Assessment of peer-related loneliness was repeated at Waves 2 and 3. Using a cohort-sequential design, a Latent Growth Curve Model was estimated. Overall, a slight increase of loneliness over time was found. However, the development of loneliness over time was found to be different for boys and girls: girls' levels of loneliness increased ove

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Gene-by-environment interaction (GxEs) studies have gained popularity over the last decade, but the robustness of such observed interactions has been questioned. The current study contributes to this debate by replicating the only study on the interaction between the serotonin transporter gene (5-HTTLPR) and perceived parental support on adolescents' peer-related loneliness. A total of 1,111 adolescents (51% boys) with an average age of 13.70 years (SD = 0.93) participated and three annual waves of data were collected. At baseline, adolescent-reported parental support and peer-related loneliness were assessed and genetic information was collected. Assessment of peer-related loneliness was repeated at Waves 2 and 3. Using a cohort-sequential design, a Latent Growth Curve Model was estimated. Overall, a slight increase of loneliness over time was found. However, the development of loneliness over time was found to be different for boys and girls: girls' levels of loneliness increased ove

Keywords

Loneliness5-HTTLPRPsychologyDevelopmental psychologyClinical psychologyBiologySerotonin transporterPsychiatry

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