Abstract 9242: Tight Regulation of Left Ventricular Transmural Filling Pressure in Healthy Individuals

TL;DRAbstract

Background: Healthy aging impairs left ventricular (LV) compliance and relaxation, which results in a decreased stroke volume in elderly individuals. By contrast, lifelong exercise training can preserve LV compliance and increase stroke volume in the elderly. However, it is unclear whether LV transmural distending pressure (LVTMP), which is thought to be the true preload for the LV, is influenced by healthy aging or lifelong exercise training. Methods: Healthy subjects (n=159; 99 male, 60 female) with no cardiovascular diseases were enrolled. Sedentary subjects were recruited from Dallas Heart Study, a multiethnic probability-based sample of Dallas County residents. Lifelong exercisers were recruited from Aerobics Center Longitudinal Study, a cohort which has documented lifelong exercise training patterns for 25 years. Subjects were stratified into 3 ‘sedentary’ age groups and 3 ‘lifelong training’ groups: Sedentary Age < 40 (n=30), Age 40-64 (n=43), and Age 65+ (n=21); Lifelong Tra

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